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Conventional computing architectures have no known efficient algorithms for combinatorial optimization tasks such as the Ising problem, which requires finding the ground state spin configuration of an arbitrary Ising graph. Physical Ising machines have recently been developed as an alternative to conventional exact and heuristic solvers; however, these machines typically suffer from decreased ground state convergence probability or universality for high edge-density graphs or arbitrary graph weights, respectively. We experimentally demonstrate a proof-of-principle integrated nanophotonic recurrent Ising sampler (INPRIS), using a hybrid scheme combining electronics and silicon-on-insulator photonics, that is capable of converging to the ground state of various four-spin graphs with high probability. The INPRIS results indicate that noise may be used as a resource to speed up the ground state search and to explore larger regions of the phase space, thus allowing one to probe noise-dependent physical observables. Since the recurrent photonic transformation that our machine imparts is a fixed function of the graph problem and therefore compatible with optoelectronic architectures that support GHz clock rates (such as passive or non-volatile photonic circuits that do not require reprogramming at each iteration), this work suggests the potential for future systems that could achieve orders-of-magnitude speedups in exploring the solution space of combinatorially hard problems. 

Abstract Successful therapies to combat microbial diseases and cancers require incorporating ecological and evolutionary principles. Drawing upon the fields of ecology and evolutionary biology, we present a systems‐based approach in which host and disease‐causing factors are considered as part of a complex network of interactions, analogous to studies of “classical” ecosystems. Centering this approach around empirical examples of disease treatment, we present evidence that successful therapies invariably engage multiple interactions with other components of the host ecosystem. Many of these factors interact nonlinearly to yield synergistic benefits and curative outcomes. We argue that these synergies and nonlinear feedbacks must be leveraged to improve the study of pathogenesis in situ and to develop more effective therapies. An eco‐evolutionary systems perspective has surprising and important consequences, and we use it to articulate areas of high research priority for improving treatment strategies.